It is important to test investigational drugs in people with the condition for which the study drug is designed. It is also important to conduct research in a variety of people because different people may respond differently to the study drug. FDA seeks to ensure that people of different ages, races, ethnic groups, and genders are included in clinical research studies.
Some people participate in research studies because they have exhausted approved treatment options – which either did not work for them, or they were unable to tolerate certain side effects. Clinical research studies may provide another option when standard therapy has failed.